dosage azone p Mono creams in vitro Percutaneous absorption of impact?

    study of penetration enhancers dosage azone on Mono p-cream skin permeation of effects and develop the optimal concentrations of nitrogen. methods using 30% ethanol-water solution as receiving fluids, mice skin in vitro as a barrier by improved penetration test in vitro of the Franz diffusion cell, HPLC method for the determination of Mo in the receptor fluid Novo benzene content. in the result 24h, azone of different concentrations on Mono cream transdermal absorption of benzene has a certain role in promoting, the enhancers 2% azone >5% azone >1% azone >0 azone. the conclusion of azone can promote Mo Mo Connaught Novo in benzene cream transdermal absorption of benzene, based on 2% effect of azone best.
    Mo Novo benzene (Monobenzone) as a powerful lightening agent for the treatment of hyperpigmentation, such as dark spots, age spots, such as melanoma, has the advantages of low toxicity and good efficacy, often made in clinical ointment or liniment, and listed in the United States Pharmacopoeia. China has yet produced. in topical skin preparations and penetration enhancers are commonly used DMSO, propylene glycol, ketones and nitrogen Terpenoids substances. the azone effect using low concentration, good , non-toxic-free stimulation advantages and are widely used. to this end, Mono p-cream was developed, and discusses the effect of azone on percutaneous permeation of Mono p-cream.
   , azone is an efficient, non-toxic, non-irritating skin permeation enhancers, which penetrate the skin to effect the orderly stacks of flattened keratinocytes, epidermal cuticle structure, and the intercellular lipid bilayer, its compactness changes, increased lipid fluidity, thereby increasing the permeability of the drug. the azone on skin permeation of many drugs promoted, which under the influence of physico-chemical properties of the drug and the media used and its concentration no necessary link. 2% azone monuobenzong cream enhancers than 5% azone, proving azone monuobenzong cream the best concentration in enhancers, not was positively correlated with concentration. Mono benzene insoluble in water and soluble in organic solvents. select sampling recovery indicators, for different receptor fluid (saline, saline, saline, saline +15% ethanol +10% ethanol +5% ethanol, saline, saline, saline +30% ethanol +20% ethanol ethyl +50% 1:1 mixed alcohol) screening results indicate that saline and 30% Ethanol mixture increases the relative standard error recovery, p Mono solubility best liquid for best reception. the penetration in vitro , magnetic stirrer speed range is typically a 100~500r · min-1. for determines best speed, respectively investigation has water bath 37 ± 1 ℃ conditions Xia, different speed (100, and 250, and 500r · min-1) Shi monuobenzong breast cream of through skin absorption situation, data displayed: different speed on monuobenzong breast cream through skin absorption not produced significantly effects, so, to better to simulation body environment, will Blender speed set for 100r · min-1. in addition, experiments, guarantee. receiving fluid level full access to rat skin in vitro, the need to prevent formation of air bubbles regularly complement receptor fluid needs with receiving solution in transdermal device to keep the temperature consistent, so as not to affect the transdermal effects.