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Company Products>BKM120  Product Introduction  See Big Picture Brief： BKM120 Nickname: NVP-BKM120,Buparlisib CAS：944396-07-0 Index: purity 99% BKM120 alias: NVP-BKM120,Buparlisib CAS:944396-07-0 index: purity 99% Description: Switzerland Novartis drug, which belongs to the Pan-PI3K inhibitor. references: 1. targets: PI3K, which when P110 α/β/γ/δ, the IC50 52 nM/166 nM/116 nM/262 nM, respectively, and reduce the effect on the VPS34,mTOR,DNAPK, PI4K beta little or no inhibitory activity. 2.http://www.yuaigongwu.com/thread-9193-2-1.HTML 3. test phase: study on Buparlisib in treatment of metastatic breast cancer is in a phase III clinical trial and validation of phase I/II clinical stage; combined fulvestrant in treatment of postmenopausal women with hormone receptor-positive, the joint HER2-locally advanced or aromatase inhibitor (AI) research in treatment of metastatic breast cancer in the phase ⅲ clinical stage Joint fulvestrant treatment of postmenopausal women with hormone receptor-positive, HER2-had previously been receiving aromatase inhibitor treatment healing or mTOR inhibitors for the treatment of locally advanced or metastatic breast cancer research in phase ⅲ clinical stage; combined with paclitaxel in the treatment of HER2-, unresectable locally advanced or metastatic breast cancer in the phase ⅲ clinical stage; joint fulvestrant treatment of postmenopausal women with estrogen-receptor positive metastatic breast cancer in a phase ⅰ clinical trial stage. 。