synergistic ketoconazole eyedrops eye filamentous fungi-resistant activity

                synergistic ketoconazole eyedrops eye filamentous fungi-resistant activity

    fungal corneal disease is blindness rates of eye disease is particularly severe fungal eye infections. due to the antifungal drug permeability difference, the curative effect is poor, fungal corneal diseases become a big problem for eye treatment, no fewer cases of enucleation was eventually forced to row. the development of high efficiency, low toxicity anti fungi, new drugs and improved formulations of existing antifungal drugs, make them synergistic attenuated, as a means of providing effective clinical treatment of fungal corneal infection is general doctors and patients need. the ketoconazole is a nitroimidazole class of broad-spectrum antifungal agents in vitro experiments show that the drugs against filamentous fungi, Candida, fungal skin and so on, there is a strong antibacterial action. the poor treatment of ocular fungal infection effect of oral and systemic side effects. since 1997, I've developed a 3% ophthalmic suspension of ketoconazole, used in the treatment of fungal keratitis, achieved a certain effect. However, the common ketoconazole pH within the range of values of the eye can withstand extremely low solubility (3 μg), the suspension of most of the drugs in a dissolved State, drug permeability difference affect the antibacterial effect of ketoconazole to play, so the formulation of clinical effect is still not satisfactory. to increased ketone Kang h drops eye liquid of anti-really bacteria effect, we from increased ketone Kang h of solubility and the permeability sex two aspects started, improved formula and the preparation process, developed out two species new of increased effect ketone Kang h drops eye liquid, this research evaluation two species increased effect ketone Kang h drops eye liquid and the ketone Kang h drops eye mixed hanging liquid in vitro the antifungal activity.